[QUOTE="not_wanted"]
Yeah but Paulescu did that before them.
BumFluff122
So? He didn't discover anything. IT was the Canadians and their tests that made the discovery. Before that it was just an idea.In 1916, he succeeded in developing an aqueous pancreatic extract which, when injected into a diabetic dog, proved to have a normalizing effect on blood sugar levels. After a gap during World War I, he resumed his research and succeeded in isolating the antidiabetic pancreatic hormone (pancreine).
From April 24 to June 23, 1921, Paulescu published four papers at the Romanian Section of the Society of Biology in Paris:
• The effect of the pancreatic extract injected into a diabetic animal by way of the blood.
• The influence of the time elapsed from the intravenous pancreatic injection into a diabetic animal.
• The effect of the pancreatic extract injected into a normal animal by way of the blood.
An extensive paper on this subject - Research on the Role of the Pancreas in Food Assimilation - was submitted by Paulescu on June 22 to the Archives Internationales de Physiologie in Liège, Belgium, and was published in the August 1921 issue of this journal.
Furthermore, Paulescu secured the patent rights for his method of manufacturing pancreine (his own term for insulin) on April 10, 1922 (patent no. 6254) from the Romanian Ministry of Industry and Trade.
Eight months after Paulescu's works were published, doctor Frederick Grant Banting and biochemist John James Richard Macleod from the University of Toronto, Canada, published their paper on the successful use of a pancreatic extract for normalizing blood sugar (glucose) levels (glycemia) in diabetic dogs. Their paper is a mere confirmatory paper, with direct references to Paulescu's article.However, they misquote that article, enunciating that:
"He [Paulescu] states that injections into peripheral veins produce no effect and his experiments show that second injections do not produce such marked effect as the first",
which is exactly the opposite of what Paulescu found out. Later on, Banting said that
"I regret very much that there was an error in our translation of Professor Paulescu's article, I cannot recollect, after this length of time, exactly what happened (...) I do not remember whether we relied on our own poor French or whether we had a translation made. In any case I would like to state how sorry I am for this unfortunate error (...)"
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