Many have the same problem, me included, but I've fixed it now. You can try this:
# Navigate to your windows folder (usually c:/windows/)
# Inside there, goto the CSC folder
# Try to open the folder and it should fail (if it doesn't, you have a different problem). It'll come up with 'You don't currently have permission to access this folder' at which time you keep pressing continue until it says you've been denied.
# Right-click the folder, go to properties.
# Go to the security tab at which point it'll say 'To continue, you must be an administrative user with permission to view this object's security properties' at which point you click continue.
# Click on admin in the owner tab which will swap the owner to the administrator then click OK.
# You then click on OK once again which will bring up the security tab.
# Tick 'full control', press OK twice to get out of the properties tabs. # Run the game.
If that doesn't work (which it didn't for me), try shutting down your anti-virus program. I use AVG and disabling it will keep L4D2 from crashing.
If these two fixes doesn't work, the only thing you can do, I guess, is wait for Valve to patch the game.
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