Question about console ports on PC

Games like Darksiders I feel would play better if I had a gamepad so I plan to maybe buy an xbox 360 gamepad to play Darksiders but my question is that when I play with a gamepad can I still use my keyboards for Hot keys? basically using both the gamepad and keyboard simulteneously.

Some support using both at once. Some don't. Can't tell you which because I don't know off the top of my head.