CCleaner is the only one I'd say everyone needs. Disable programs and services you don't need. If you want the best and fastest defragmentation, Perfectdisk is what I use, but it costs money. It you aren't going to get a good one, you might as well just use the default Windows.
Don't bother with getting programs to free up ram or defragment your registry. Defragging the registry is too risky for the possible milliseconds of load time you might gain on launching programs, and your ram will automatically be cleared when you restart Windows. If you have programs that still use up your ram, like I said earlier, disable unnecessary programs and services with CCleaner.
One program you may want to look at if you're too lazy to do that other stuff yourself is GameBooster. It can automatically try to scan for unnecessary services and disable them when you enter gaming mode and then reenable them afterwards.
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