DS is possible.
I usually multitask, and I frequently play Zelda and FFIII one handed.
Movement and attacks are made via touch pad in Zelda. The only time you need to use the Dpad is when you want to open inventory.
FFIII, the touchpad can be used for combat and it is turn base combat. You will have to free roam using the Dpad.
I cannot remember if Trauma Center uses the Dpad, all of the surgery stuff is done via touchpad.
Not sure about PSP, I am still waiting for Best Buy to get the black slim in. Any one tried playing FFI or FFII on PSP one handed?
I hope this works out for you.
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