There can be VERY noticeable differences between lossy and lossless multichannel audio. DTS HD MA and Dolby True HD generally sound deeper, richer, broader, louder, more detailed, and more dynamic than standard lossy DTS and Dolby Digital.
Well, obviously TrueHD is gonna sound a lot better than Dolby Digital's mere 640 kbps. But the difference between DTS and HD MA or DTS and TrueHD? No, I don't think it's that significant at all.
In this case, it depends on the individual movie you're watching. There is a huge difference in sound quality between the dvd DTS track and the blu-ray DTS HD MA track for the Simpsons Movie. For many movies, there is a big difference, and for many others, not so much. The DTS and DTS HD tracks for Hannibal sound almost identical.
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