@horgen: Don't worry, you will have plenty of points to spend. (As I said I am around 50 lvl without even choosing faction in main quest and not even completing any dlc, although I got season's pass.)
Also most of these require a minimum level to unlock, so you would just need a few points in the begining.
Prices for non-reference GTX1060 start from £229 in UK shops. While the cheapest RX480 8GB which is reference :/, costs just £10 less in the same store.
The card I linked before costs £238 in the same shop. :P
You can follow from your pipboy the main quest (it marks your map where to go) and in the same time, you can do some side quests here and there. There are a lot of sidequest and there is a huuuuge map to explore. After 200+ hours, I haven't discovered even the half map and I haven't finished the main quest, I didn't even choose faction yet...
About perks. I would advise you to see what weapon you like to use and choose to upgrade the damage with them. (Like Rifleman or Commando or both and many others :P).
Also I would advise you to learn crafting which requires Science rank 4 + Gun nut rank 4 and probably Armorer rank 4 aswell.
Hacker rank 3 + Locksmith rank 3 (rank 4 seems useless for both) in order to open all doors in the game.
These are 23 skills (with minimum 1 weapon type selected +5 for each other) that I highly recommended for making your life easier in Fallout 4.
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