the only glitches i had issues with (bought it on day 1) was the radscorpions falling through the ground, and occasional freezing (personally, nothing to ruin the game for me) and after the the second patch I didn't have issues after that but I haven't played since november
I'm not so sure, but I will give you some advice, and this is just what I did. You should make a key save when about every quest line is open and just leave it alone so you can go through about every ending or in case you do something you wished you hadn't.
SgtSchfiftyFive
thats what i did just to be able to play through all the different endings, but in response to the OP if you have killed house then from here on you should be able to pick between yes man, ncr and cesar
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