Well, the amount of enemies on screen will be sacrificed, the foliage and trees will look bad, lighting will be poorer, AI is gonna be worse and I don't think co-op would be possible on Wii hardware.
Part of the atmosphere of RE 5 is the graphics. If the graphics are lowered, then so too will be the atmosphere.
RE 5 should be played on the other consoles. A port would slaughter the game.
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