Reality Check - Could we clone Big Boss? The Science of Metal Gear Solid

Cam puts his biology degree to use as he investigates the cloning of Big Boss and Metal Gear's Les Enfant Terrible project.

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Reality Check

Reality Check

Airs Thursdays at 12pm PT

Flex those mental muscles and join Lucy James on a journey of discovery in Reality Check, the show that investigates the science behind your favourite games, and spawns a few wild theories of its own.

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Mrod1212

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Edited By Mrod1212

Why is it all black past 6 minutes? Anyways, entertaining as always.

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Loon86

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Edited By Loon86

Any cell, except sperm, egg and, possibly, neurons.:) There are recent studies that show that DNA from a neuron has an unique genome pattern. (Maybe DNA from neurons are used to store data - this is just a personal speculation, of course.)

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cantante80

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@loon86 Don't forget red blood cells as they lose their Nucleus as they mature.

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Halloll

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@loon86 is that unique to each individual neuron or shared among them?

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amdreallyfast

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I guess Plasma Snake wasn't predictable enough to be noticed

(sorry; I tried for 10min to think of a good plasma pun, but I couldn't)

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SolidSnakeJT

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video becomes black at 6:33!

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Halloll

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@SolidSnakeJT this video suffered from accelerated aging and died early.

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poormallard

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Edited By poormallard

@Halloll @SolidSnakeJT Sorry about that, we're just fixing it now. There was a hiccup with the HD version of the video.

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poormallard

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@Halloll @SolidSnakeJT All better now!

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crazeon

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@SolidSnakeJT same thing happened to me, I just had to refresh the page and skip to where I left off

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bullet_dud

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@crazeon @SolidSnakeJT Did that too but it always fails at 6:33 no matter what quality/refresh cycle/skip ahead :/

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amdreallyfast

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@SolidSnakeJT yeah, same for me; bummer too, because it was really interesting

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Wej_accept_it

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@amdreallyfast @SolidSnakeJT Same here, what the?

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deactivated-58a78a043e9d4

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@Wej_accept_it @amdreallyfast@SolidSnakeJT @crazeon Change the quality level, that'll force it to refresh that section.

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catoblepas

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Edited By catoblepas

@kitmeep If they cancel this show there will be no reason at all to come back to gamespot, bad enough that they are cancelling feedbackula.


You don't know what you're talking about, this show is great and well thought through. Keep it up Cam!

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Avatar image for deactivated-58a78a043e9d4
deactivated-58a78a043e9d4

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@catoblepas @kitmeep Oh man. I just got a bad feeling that they're going to replace Feedbackula with an American show. Those guys have the humour of a damp fish.

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Boost120

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Is there any real world information on clones of clones? Often see clones of clones being stupid versions of the original in fantasy.

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Lambchopzin

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@Boost120 The mice that were mentioned at the end are specifically a real example of that. I remember reading about that before, if I'm remembering right they successfully cloned 25 generations of the first clone that were healthy and had normal lifespans, after that they started to run into problems I guess.


That's the gist of it anyways. Those mice are the only example of this as far as I know, though.

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Talok

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Hwatts this!? A lovely scientific discussion on cloning woefully underpopulated with bees? This briefcase full of bees ought to take care of it!

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Boost120

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Edited By Boost120

@kitmeep if you don't like it, don't watch. I thoroughly enjoy this series.

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amdreallyfast

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@Boost120 @kitmeep Let him have his voice. It is quite valid to voice a dissenting opinion of something that you used to like but that you think has degraded in quality. Simply not watching it will make his complaints go away, but won't deal with what he believes is a problem.

I disagree with him, but I'll defend his right to dissent :)

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deactivated-58a78a043e9d4

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@02pheland @amdreallyfast @Boost120 @kitmeep Everyone else also has a right to tell him to stop being such a dweeb.

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02pheland

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@amdreallyfast @Boost120 @kitmeep its fine to have an opinion and to share it but by just saying something is bad and not giving any reason why then its not helpful at all and is just complaining for the sake of complaining. Ill also defend a persons right to have a different opinion but only if they logically can explain why they have it.

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WitIsWisdom

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Could they actually clone a fictional video game character?


What can be said about this... the cool thing about it being a game is that it IS a game... Anything can happen.


Who the hell cares if it is possible in real life or not?

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karloss01

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@WitIsWisdom swing and a miss...

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West123

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@karloss01 @WitIsWisdom question is why did anyone like his comment???

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ArchoNils2

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You really need to google what cloning is if that question was serious. Also you did not get the point of this show.

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SnakeLegendary

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...!.... No, i no need more sons.¬¬

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TehUndeadHorror

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Nice explanations!

The theoretical process for cloning is sound, but the methodology requires refining. There's a serious lack of egg donors for the number of eggs that are wasted, so a reduction in failures is needed to move the science forward.

It's definitely a messy topic ethically, though.

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deactivated-60b838d2a137f

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@kitmeep If you say so... I've been watching them, and they seem to have a pretty consistent quality to them if you ask me.

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dribblesbarbax

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Beads? GOB's not on board.

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deactivated-60b838d2a137f

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Holy shit, that's a creepy Big Boss/Cam crossover image...

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je29836

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Edited By je29836

a human being has definitely been cloned already but no doctor/company/government will admit it because of current ethical/religious/legal controversies. it is an inevitability that human cloning will become common practice down the road though, nobody can stop technological advancement.

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BrunoBRS

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you didn't comment on the silliest aspect of cloning in MGS: the fact that according to the end of the first metal gear solid, solid snake possesses only the "dominant genes" of big boss, and liquid has the recessive.


as far as my understanding of genetics goes, i'm pretty sure you can't clone someone and then get rid of a good chunk of their genes before the embryo develops, and genetic engineering to swap those genes from dominant to recessive and vice versa would result in grossly different results that might as well be a whole new person (not to mention all the syndromes and diseases tied to dominant/recessive genes that you would definitely not want in your super soldier)

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sudarsanvrs

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@BrunoBRS but solid wasn't a prefect solider either he was just better than liquid , whole theme of mgs 1 is to prove gene has nothing to do with one's ability .solid beat liquid only because he is more talented and exp'ed than liquid and it has nothing to do with genes or anything. as far as solidus, meh i can buy that as part of the fiction.

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ExtremePhobia

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@BrunoBRS As far as I'm aware, this type of cloning isn't currently possible. The only REAL barrier at the moment is the ability to separate paired genes. While I'm not sure that it's possible yet, I don't know that it's going to be THAT impossible to do. The body already naturally makes these separations when it creates the reproductive cells. It can't pass on both genes, only one and so the genes must be separated/created in such a way that only one is passed on.

The trouble is more in reproducing this biological event. Science has always had trouble with this kind of thing. I'm sure it's not going to be easy. But I'm almost certain it will happen.

As to the negative traits that come from having only dominant or recessive traits:

A) Liquid actually mentions this if I remember. He's had a slightly more troubling life because he's had to contend with some defects as a result of getting the recessive genes. I may not be remembering this correctly but I feel like the topic was touched on.

B) There isn't an inherent problem with it. Dominant and Recessive is a very binary system when really it's more like a spectrum. The scale could have thousands of points of expression on it. So the idea that having only one or the other would inherently be dangerous isn't entirely true. The danger is more that we would be forcing the expression of certain genes when we don't necessarily know the properties of the genes.

The bigger problem with this is really more the feasibility of such of a feat (I think) than the outcome of such an effort. Of course, some of those recessive genes may have given Solid Snake a better soldiering genome. That's a different topic though.

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BrunoBRS

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@ExtremePhobia @BrunoBRS yeah i know it's not possible (and if it was, it would be a massive hurdle, like you said), which is why i was wondering if he would touch on that.

as for A) he might, but there are genetic "defects" tied to dominant genes too. it's a common misconception (which kojima fell prey to) that recessives are the only ones that can have bad traits.but the main point i wanted to drive with my comment is how silly it is to think you'll create better soldiers by going through that hassle to split the genes (something that admitedly, the game brings up with solidus)

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Renoo27

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Great episode, Cam! Love the Metal Gear series. Just want to add yeah it does seem environment is most important, as shown in MGS2, since a super soldier WAS created without all the cloning business in the form of Raiden. As Ocelot put it: "Given the right situation, the right story, anyone can be shaped into Snake."

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PETERAKO

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vid stops at 6:33 o.O

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ExtremePhobia

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@PETERAKO I have that problem too. Usually it's during peak hours. This doesn't generally happen with other video players - they just hiccup and then start playing again but the CBSi player seems to just lose the feed all together for some reason. Lowering the quality usually solves the problem.

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poormallard

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@ExtremePhobia @PETERAKO Sorry about that, we're just fixing it now.

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PS4andXoneGamer

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@PETERAKO Set the quality to low. Usually sorts it out

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PS4andXoneGamer

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Edited By PS4andXoneGamer

I love the MGS series but story wise, it just confuses the life out of me. I don't even try to figure out whats going on in MGS games anymore, I just strap in and enjoy the ride

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deactivated-60b838d2a137f

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@PS4andXoneGamer I just love how they blend realistic historical and real world elements (like actual military practices and tactics, and historical agencies and treaties and the like) with totally absurd science-fiction stuff, it's such a great blend! It sure makes a convoluted story, but the parts you can actually wrap your head around are a lot more interesting because of it's ties to actual, real, history and fact.

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