Well in general I find it best to not attempt to hit anybody as it's possible to break something due to an odd strike against bone. It's usually best to keep your ego in check or attempt to physically squash the threat with some well-timed pushing, pulling, or wrestling tactics in the hope that people will jump in to break it all up and everyone can shout their traditional verbal threats and we can all go on our way.
Failing that sometimes it's necessary to fall to strikes and to me it really doesn't make any difference if they're male or female -- if they're enough of a threat that I have to resort to hard strikes then I'm going to try to take them down regardless. I know some female kickboxers that are in much better shape than I am and, given the opportunity and range, they will knock me out as I am not a giant moose of a man.
Obviously women are, in general, easier to control in a grapple situation so most likely I would just try to fend them off without it falling to physical violence.
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