"For example, a city called Megaton was built around a crater where a nuclear bomb fell but never detonated." Link
"At one point we set one of the exploding nuclear cars on fire and then hopped into a portable nuclear shelter (which costs a quarter to use and looks like a phone booth) to avoid the blast." Link
"Pulling the Fat Man from our shoulder pack, we launched several explosives roughly the ****of footballs at the feet of the behemoth, making light work of the creature – it only took 5 nukes." Link
"We came across a Behemoth Super Mutant - one of the game's bosses - that could only be taken down easily with this device. The small nuclear explosions are fantastic, and those worried about balance will be relieved to know that it took several of them to bring him down." Link
"Feral ghouls are extremely swift and vicious and come leaping at you with tremendous speed." Link
"but there were also Glowing Ghouls who have fully absorbed the radioactivity and effectively heal their brethren by a radioactive burst of curative fluids." Link
Zapping the player with radiation attack. Link
"eventually make your character extremely ill if you let them zap you with their radiation-based attacks." Link
"Poor INT will NOT affect your dialogue choices." Link
"Most of the weapons and armors (even power armor and turbo plasma) can be found by in early parts of the game, but they have their disadvantages" Link
"The Pip-Boy has a radar on which the opponents are visible. Its range depends on the player's perception." Link
"The only time we really level stuff to your character is when we lock you in an area you can't leave, we don't want the enemies you're fighting to be grossly out of proportion to your character because you can't leave." Link
Flaming sword: Link
Suck-o-tron: Link
Toaster weapon: Link
Bobble heads increase stats: Link
Nerfed combat & less consequences: Link
No xp from sneaking, have to kill them: Link
"You laugh your ass off when you see a mutant's leg get blown off. It never gets old - it hasn't yet." Link
"The dark humor of talking to an old lady who's really nice to you, and then blow her head off, put her head on a counter, and pretend to talk to her...there's a certain charm to that." Link
"Had they not been identified as the Brotherhood of Steel (multiple times), I would not for the life of me have guessed who they were. They are described as "noble knights of the wasteland" setting out to beat the supermutants while swearing and behaving like average US soldier clichés." Link
"They're worried whether the VATS slo-mo is practical with the multitude of fights in FO3. 10 seconds of non-interactive cutscene during every shot?" Link
Town level cap: Link

Now, those points (with links) highlight the elements which do not belong in a Fallout game. I wrote that before the fan interview which confirmed the hand holding of the quest compass, how combat was nerfed to be more shootery, only 13 skills, perks being merged with traits, the teddy bear dismemberment, the toning down of all the themes, how the karma system affects nothing, how all the quests are independant of eachother, fast travelling, killing 3 super mutants at level 3 with a baseball bat and the removal of meaningful consequences to your choices.

EDIT: the links didn't work, here is the original message, just scroll down the thread:

http://www.gamespot.com/pages/forums/show_msgs.php?topic_id=26572877