Most heroin overdoses are caused by the illegal drug market. Let's say that I am a typical heroin user. I buy a product that is usually 40-60% heroin and the rest is filler or whatever it's cut with. I get used to taking a certain dose of this heroin in order to achieve a certain effect. Now let's say I am at party, and a guy there has some heroin. His product is much better than what I am used to and is 95% actual heroin. I cannot possibly know this, as street heroin doesn't come with a nutritional facts label. I shoot up my usual dose and I die because I took much more than I intended. Decriminalizing and regulating heroin sales would solve this problem.
Also, do you really think someone should be arrested for shooting up? Do you think they belong in jail, alongside murderers and rapists, because they use a substance that feels damn good? I'm not saying heroin isn't dangerous and addictive, but if you ask me, turning users into criminals doesn't help them. A rehab center would probably do them far more good than a prison cell.
Finally, mdma (ecstasy) is one of the safest drugs out there when used in moderation. I've honestly never heard of what you mentioned, but even if it were the case, wouldn't it be easier to know if you had that predisposition if you could speak openly and honestly with doctors about it, or maybe even have them run a controlled test dosage to gauge your reaction?
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