I think Halo 3, Mass Effect, Metroid Prime 3, Mario Galaxy, and Bioshock are the big stars. I'm personally most looking forward to Mass Effect, the concept, the graphics, the gameplay and the scale of the game looks amazing.
XBOX360 is getting killer apps this holidays getting further ahead than the ps3. In graphics a lot of people will dissapointed to see the ps3's graphics not any better than the XBOX360's even though it's released about one year later. With poor titles and shortages, the ps3 doesn not have a bright future looking at the long run.
themyth01's comments